From the George airport take the N2 highway heading east - towards Port Elizabeth. Continue on the N2, travelling through the picturesque towns of Wilderness, Sedgefield and Knysna.
Take the Plettenberg Bay exit at the Shell Ultra City Service station - turn right into Marine Way. Continue on Marine Way until you reach a traffic circle / roundabout. Turn left into Main Road. After about 200 metres (656.1 feet), turn right into Church Street. You will see a hotel signpost at this intersection. The Plettenberg Hotel is at the end Church Street - number 40. Driving time is 1 hour and 15 minutes.